Built to show you what's working
Core100 isn't a bottle you finish and wonder if it did anything. It's a 90-day protocol with two blood tests included - one at the start, one at day 90. You'll see your baseline. You'll see what changed. No other product in this category does this.
Built to show you what's working
Core100 isn't a bottle you finish and wonder if it did anything. It's a 90-day protocol with two blood tests included - one at the start, one at day 90. You'll see your baseline. You'll see what changed. No other product in this category does this.
Built to show you what's working
Core100 isn't a bottle you finish and wonder if it did anything. It's a 90-day protocol with two blood tests included - one at the start, one at day 90. You'll see your baseline. You'll see what changed. No other product in this category does this.
Backed by clinical research
What Actually Changes After 50 - and What You Can Do About It
What Actually Changes After 50 - and What You Can Do About It
Core100 is a 90-day protocol built around 13 researched ingredients that support the five biological systems responsible for your energy, mental clarity, heart health, sleep, and physical resilience. It includes two blood tests so you can see what's working.
Core100 is a 90-day protocol built around 13 researched ingredients that support the five biological systems responsible for your energy, mental clarity, heart health, sleep, and physical resilience. It includes two blood tests so you can see what's working.
The Protocol
Five things your body needs more of after 50
01 - Energy
Steady energy that lasts past 2pm
Core100 delivers NMN, a direct NAD+ precursor studied in a 12-week randomized controlled trial with adults aged 65 to 75, alongside CoQ10 in Ubiqsome® phytosome form, which achieves approximately 3x higher absorption than standard CoQ10. A placebo-controlled trial using this exact CoQ10 dose and form showed support for blood vessel function and antioxidant capacity. The result is not a spike. It is the kind of even energy you used to take for granted.
01 - Energy
Steady energy that lasts past 2pm
Core100 delivers NMN, a direct NAD+ precursor studied in a 12-week randomized controlled trial with adults aged 65 to 75, alongside CoQ10 in Ubiqsome® phytosome form, which achieves approximately 3x higher absorption than standard CoQ10. A placebo-controlled trial using this exact CoQ10 dose and form showed support for blood vessel function and antioxidant capacity. The result is not a spike. It is the kind of even energy you used to take for granted.
01 - Energy
Steady energy that lasts past 2pm
Core100 delivers NMN, a direct NAD+ precursor studied in a 12-week randomized controlled trial with adults aged 65 to 75, alongside CoQ10 in Ubiqsome® phytosome form, which achieves approximately 3x higher absorption than standard CoQ10. A placebo-controlled trial using this exact CoQ10 dose and form showed support for blood vessel function and antioxidant capacity. The result is not a spike. It is the kind of even energy you used to take for granted.
02 - Mental clarity
The word on the tip of your tongue
Your brain consumes 20% of your body's energy but gets less of it as mitochondrial efficiency declines. Some cognitive changes after 50 may be connected to how efficiently brain cells produce and use energy. Core100 includes PQQ (as PureQQ®) at the exact dose used in clinical studies showing improved cognitive function in older adults. The protocol also delivers activated B-vitamins, including methylfolate, methylcobalamin, and P5P, in forms that support methylation pathways affected by common genetic variation. Standard B-vitamins require conversion steps that slow down with age and genetic variation. These are already in their active forms.
02 - Mental clarity
The word on the tip of your tongue
Your brain consumes 20% of your body's energy but gets less of it as mitochondrial efficiency declines. Some cognitive changes after 50 may be connected to how efficiently brain cells produce and use energy. Core100 includes PQQ (as PureQQ®) at the exact dose used in clinical studies showing improved cognitive function in older adults. The protocol also delivers activated B-vitamins, including methylfolate, methylcobalamin, and P5P, in forms that support methylation pathways affected by common genetic variation. Standard B-vitamins require conversion steps that slow down with age and genetic variation. These are already in their active forms.
02 - Mental clarity
The word on the tip of your tongue
Your brain consumes 20% of your body's energy but gets less of it as mitochondrial efficiency declines. Some cognitive changes after 50 may be connected to how efficiently brain cells produce and use energy. Core100 includes PQQ (as PureQQ®) at the exact dose used in clinical studies showing improved cognitive function in older adults. The protocol also delivers activated B-vitamins, including methylfolate, methylcobalamin, and P5P, in forms that support methylation pathways affected by common genetic variation. Standard B-vitamins require conversion steps that slow down with age and genetic variation. These are already in their active forms.
03 - Sleep
Sleep that actually restores you
If you wake up tired no matter how many hours you got, the problem isn't your sleep schedule. It's what your cells are doing (or not doing) overnight. Two Core100 ingredients, NMN and PQQ, have independently shown improvements in sleep quality in clinical studies with older adults. NMN was studied in adults aged 65 to 75 over 12 weeks. PQQ was studied at the exact dose included in this protocol. Better-fueled cells recover more efficiently overnight. You feel it the morning after.
03 - Sleep
Sleep that actually restores you
If you wake up tired no matter how many hours you got, the problem isn't your sleep schedule. It's what your cells are doing (or not doing) overnight. Two Core100 ingredients, NMN and PQQ, have independently shown improvements in sleep quality in clinical studies with older adults. NMN was studied in adults aged 65 to 75 over 12 weeks. PQQ was studied at the exact dose included in this protocol. Better-fueled cells recover more efficiently overnight. You feel it the morning after.
03 - Sleep
Sleep that actually restores you
If you wake up tired no matter how many hours you got, the problem isn't your sleep schedule. It's what your cells are doing (or not doing) overnight. Two Core100 ingredients, NMN and PQQ, have independently shown improvements in sleep quality in clinical studies with older adults. NMN was studied in adults aged 65 to 75 over 12 weeks. PQQ was studied at the exact dose included in this protocol. Better-fueled cells recover more efficiently overnight. You feel it the morning after.
04 - Heart health
Your heart runs on CoQ10. You're making less of it.
CoQ10 production drops with age, and it drops further if you take statins. Your heart muscle, the most energy-demanding tissue in your body, depends on it. Core100 delivers CoQ10 in Ubiqsome® phytosome form, which was shown in a placebo-controlled clinical trial to support blood vessel function at this exact dose and form. The protocol also supports healthy homocysteine levels through activated folate, B12, and B6. Homocysteine is one of the two markers measured in your included blood tests, so you will see your own baseline and day-90 values.
04 - Heart health
Your heart runs on CoQ10. You're making less of it.
CoQ10 production drops with age, and it drops further if you take statins. Your heart muscle, the most energy-demanding tissue in your body, depends on it. Core100 delivers CoQ10 in Ubiqsome® phytosome form, which was shown in a placebo-controlled clinical trial to support blood vessel function at this exact dose and form. The protocol also supports healthy homocysteine levels through activated folate, B12, and B6. Homocysteine is one of the two markers measured in your included blood tests, so you will see your own baseline and day-90 values.
04 - Heart health
Your heart runs on CoQ10. You're making less of it.
CoQ10 production drops with age, and it drops further if you take statins. Your heart muscle, the most energy-demanding tissue in your body, depends on it. Core100 delivers CoQ10 in Ubiqsome® phytosome form, which was shown in a placebo-controlled clinical trial to support blood vessel function at this exact dose and form. The protocol also supports healthy homocysteine levels through activated folate, B12, and B6. Homocysteine is one of the two markers measured in your included blood tests, so you will see your own baseline and day-90 values.
05 - Physical resilience
Do more without paying for it the next day
A walk that leaves you sore for three days. Yard work that wipes out your weekend. After 50, physical effort costs more than it used to. Core100 includes PrimaVie® purified shilajit, studied in a controlled trial with adults aged 45 to 55 for physical performance, and NMN, shown to maintain walking speed in adults aged 65 to 75. R-Alpha Lipoic Acid in a stabilized, high-absorption form (Bio-Enhanced®) supports your body's antioxidant recycling system, helping manage the oxidative stress that accumulates after physical activity.
05 - Physical resilience
Do more without paying for it the next day
A walk that leaves you sore for three days. Yard work that wipes out your weekend. After 50, physical effort costs more than it used to. Core100 includes PrimaVie® purified shilajit, studied in a controlled trial with adults aged 45 to 55 for physical performance, and NMN, shown to maintain walking speed in adults aged 65 to 75. R-Alpha Lipoic Acid in a stabilized, high-absorption form (Bio-Enhanced®) supports your body's antioxidant recycling system, helping manage the oxidative stress that accumulates after physical activity.
05 - Physical resilience
Do more without paying for it the next day
A walk that leaves you sore for three days. Yard work that wipes out your weekend. After 50, physical effort costs more than it used to. Core100 includes PrimaVie® purified shilajit, studied in a controlled trial with adults aged 45 to 55 for physical performance, and NMN, shown to maintain walking speed in adults aged 65 to 75. R-Alpha Lipoic Acid in a stabilized, high-absorption form (Bio-Enhanced®) supports your body's antioxidant recycling system, helping manage the oxidative stress that accumulates after physical activity.
Trusted by Practitioners
Trusted by Practitioners
Keshav K. Singh
PhD
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
"For almost 30 years, my work has centered on mitochondrial dysfunction as a driver of aging. Core100 applies a dual-action strategy, combining support for improving mitochondrial health with antioxidant defense."
Keshav K. Singh
PhD
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
"For almost 30 years, my work has centered on mitochondrial dysfunction as a driver of aging. Core100 applies a dual-action strategy, combining support for improving mitochondrial health with antioxidant defense."
Research & Development
We turn insights into hypotheses, build and test prototypes fast, validate with data and experts, then iterate into a manufacturable, compliant product.
One protocol. Five systems. Proof included.
Core100 is a 90-day protocol with 13 researched ingredients supporting energy, mental clarity, heart health, sleep, and physical resilience. Every order includes two blood tests through Quest Diagnostics.
More consistent energy
Improved focus and mental speed
Daily recovery and resilience
Support for healthy aging, skin, and cells
$99/mo
$149/mo
$149/mo
New -30% lower price
90-Day Subscription delivered and billed every 90 days. Pause or cancel anytime.
Two Rerise Biomarker Tests included.
Free U.S. shipping.
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One protocol. Five systems. Proof included.
Core100 is a 13-active mitochondria and NAD+ protocol designed to support cellular energy, cognitive performance, and healthy aging.
More consistent energy
Improved focus and mental speed
Daily recovery and resilience
Support for healthy aging, skin, and cells
$99/mo
$149/mo
New -30% lower price
90-Day Subscription delivered and billed every 90 days. Pause or cancel anytime.
Two Rerise Biomarker Tests included.
Free U.S. shipping.
People usually ask about
How is Core100 different from a multivitamin or CoQ10 I'd buy at the store?
A multivitamin is broad nutrient coverage. A basic NAD+ booster usually targets one pathway. Core100 is designed around five interconnected systems so you’re supporting the environment your mitochondria operate in - not just one lever.
When will I notice a difference?
You don’t need to “cycle” Core100 the way you might with stimulant-based products. Most people run it as a 90-day protocol, then continue taking it daily.
I already take several things. Can I take Core100 alongside them?
Often, yes. The main consideration is overlap - if you’re already taking separate NAD+ precursors, mitochondrial blends, CoQ10, or similar products, you may be doubling up.
What do the blood tests measure?
A standard multivitamin covers broad micronutrient gaps but doesn’t specifically target how your cells make and manage energy. Core100 is built around mitochondrial and NAD+ systems, with ingredients and doses chosen for those functions rather than general coverage. Many people use both: a basic multivitamin as “background insurance” and Core100 as a focused energy and resilience protocol.
Where is Core100 made?
People usually ask about
How is Core100 different from a multivitamin or CoQ10 I'd buy at the store?
A multivitamin is broad nutrient coverage. A basic NAD+ booster usually targets one pathway. Core100 is designed around five interconnected systems so you’re supporting the environment your mitochondria operate in - not just one lever.
When will I notice a difference?
You don’t need to “cycle” Core100 the way you might with stimulant-based products. Most people run it as a 90-day protocol, then continue taking it daily.
I already take several things. Can I take Core100 alongside them?
Often, yes. The main consideration is overlap - if you’re already taking separate NAD+ precursors, mitochondrial blends, CoQ10, or similar products, you may be doubling up.
What do the blood tests measure?
A standard multivitamin covers broad micronutrient gaps but doesn’t specifically target how your cells make and manage energy. Core100 is built around mitochondrial and NAD+ systems, with ingredients and doses chosen for those functions rather than general coverage. Many people use both: a basic multivitamin as “background insurance” and Core100 as a focused energy and resilience protocol.
Where is Core100 made?