3079 reviews
★★★★★ 4.9/5
Mitochondrial and NAD+ Support
A foundational protocol for mitochondrial function and NAD+ support, built for energy, cognition, resilience, and healthy aging.
Quarterly subscription
$4.99/day
Save $51
$500
$449
Most popular
Annual subscription
$3.60/day
Save $718
$2017
$1299
Best value
One time purchase
90 day supply $499
Third-Party Tested
Non-GMO
Additive-Free
Gluten-Free
U.S. GMP Certified
Made in USA
Ingredient Spotlight
Every ingredient has a functional role.
Every ingredient has a functional role.
Each ingredient is mapped to key areas of NAD+ metabolism, mitochondrial function, redox balance, methylation, and metabolic flexbility, optimizing your health everyday.
Each ingredient is mapped to key areas of NAD+ metabolism, mitochondrial function, redox balance, methylation, and metabolic flexbility, optimizing your health everyday.
R-Lipoic Acid
Bio-Enhanced® NaRLA
Vitamin B12
Methylcobalamin
Terminalia chebula
as YuvaBio® Y100™
Vitamin B6
Pyridoxal-5'-phosphate
Purified Shilajit Extract
PrimaVie®
NMN
Nicotinamide mononucleotide
Clinically studied ingredients. Clinically dosed. Third-party tested.
Core100 combines thirteen clinically-informed actives to support your body’s five core energy systems.
Folate (5-methyltetrahydrofolate)
As Quatrefolic®
PQQ
As PureQQ®
Acetyl-L-Carnitine
ALCAR HCl
Trimethylglycine
Betaine
Niacin
As UbiQsome® Phytosome™
CoQ10
UbiQsome® Phytosome™
Vitamin B2
Riboflavin-5'-Phosphate
Your new 90-day rebuild
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Hour
6
Early cell activation
Within the first few hours, mitochondrial nutrients are absorbed and begin feeding the machinery that turns food into usable energy.
Day
7
Smoother energy processing
B vitamins and methyl donors are building to steadier levels, supporting cleaner, more efficient daily energy metabolism.
Day
30
More efficient cellular recharge
Repeated dosing supports stronger NAD+ and mitochondrial enzyme activity, improving how cells recharge between everyday demands.
Day
60
Steadier everyday energy
Mitochondria-supporting nutrients work together so cellular energy output is more resilient and day-to-day stamina feels steadier.
Day
90
Built-up cellular resilience
Ongoing support for mitochondria, methylation, and antioxidant defenses reinforces the resilience of systems that drive energy and focus.
Day
180
A stronger baseline
Maintained nutrient levels help preserve gains in mitochondrial efficiency and homocysteine management.
Beyond
Ongoing cellular maintenance
Continued use maintains this mitochondrial and methylation support so cells keep pace with aging and modern stress.
Year
1
Encourages the growth of fresh, more resilient mitochondria
Year
2
Encourages the growth of fresh, more resilient mitochondria
Hour 6
Day 7
Day 30
Day 60
Day 90
Day 180
Beyond
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Hour
6
Early cell activation
Within the first few hours, mitochondrial nutrients are absorbed and begin feeding the machinery that turns food into usable energy.
Day
7
Smoother energy processing
B vitamins and methyl donors are building to steadier levels, supporting cleaner, more efficient daily energy metabolism.
Day
30
More efficient cellular recharge
Repeated dosing supports stronger NAD+ and mitochondrial enzyme activity, improving how cells recharge between everyday demands.
Day
60
Steadier everyday energy
Mitochondria-supporting nutrients work together so cellular energy output is more resilient and day-to-day stamina feels steadier.
Day
90
Built-up cellular resilience
Ongoing support for mitochondria, methylation, and antioxidant defenses reinforces the resilience of systems that drive energy and focus.
Day
180
Built-up cellular resilience
Maintained nutrient levels help preserve gains in mitochondrial efficiency and homocysteine management.
Beyond
Ongoing cellular maintenance
Continued use maintains this mitochondrial and methylation support so cells keep pace with aging and modern stress.
Year
1
Encourages the growth of fresh, more resilient mitochondria
Year
2
Encourages the growth of fresh, more resilient mitochondria
Hour 6
Day 7
Day 30
Day 60
Day 90
Day 180
Beyond
Hour
6
Early cell activation
Within the first few hours, mitochondrial nutrients are absorbed and begin feeding the machinery that turns food into usable energy.
Day
7
Smoother energy processing
B vitamins and methyl donors are building to steadier levels, supporting cleaner, more efficient daily energy metabolism.
Day
30
More efficient cellular recharge
Repeated dosing supports stronger NAD+ and mitochondrial enzyme activity, improving how cells recharge between everyday demands.
Day
60
Steadier everyday energy
Mitochondria-supporting nutrients work together so cellular energy output is more resilient and day-to-day stamina feels steadier.
Day
90
Built-up cellular resilience
Ongoing support for mitochondria, methylation, and antioxidant defenses reinforces the resilience of systems that drive energy and focus.
Day
180
A stronger baseline
Maintained nutrient levels help preserve gains in mitochondrial efficiency and homocysteine management.
Beyond
Ongoing cellular maintenance
Continued use maintains this mitochondrial and methylation support so cells keep pace with aging and modern stress.
What benefits to expect?
Real energy doesn’t spike. It builds week by week, system by system.
Hour 6
Day 7
Day 30
Day 60
Day 90
Day 180
Beyond
How Core100 works for you
Step 1 - Boosts NAD+ recycling
Increases the pool of NAD+ your cells use to turn food into energy and carry out everyday repair work.
Step 2 - Improves ATP production
Improves how your mitochondria turn oxygen and nutrients into ATP, so cells have more usable energy to work with.
Step 3 - Enhances fuel delivery
Helps shuttle fat-based fuel into your mitochondria and keep their core enzymes performing well under everyday metabolic stress.
Step 4 - Strengthens oxidative defenses
Activates renewal pathways and reinforces antioxidant defenses that protect mitochondrial function over time.
Five systems. One protocol.
Core100 maps 13 actives to five core systems to support energy, cognition, and resilience.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Built for the long-term
Built for the long-term
Core100 is powered by 13 actives supporting your cellular energy systems.
Core100 is powered by 13 actives supporting your cellular energy systems.
Core100 is powered by 13 actives supporting your cellular energy systems.
Increased NAD+
Randomized trials of NMN in adults 40–65 show meaningful rises in blood NAD+.
Stronger Defenses
A meta-analysis of randomized trials found alpha-lipoic acid significantly reduced circulating inflammatory and oxidative-stress markers, including CRP, IL-6, and TNF-α, compared with placebo.
Inflammatory markers reduced vs placebo
CRP
-10%
IL-6
-20%
TNF-α
-25%
Systematic review and meta-analysis of 20 RCTs; alpha-lipoic acid significantly lowered CRP, IL-6 and TNF-α versus placebo.
Cognitive Clarity
Randomized, double-blind trials in middle-aged and older adults show that PQQ supplementation improves multiple cognitive domains versus placebo, including memory, attention, and processing speed.
Cognitive improvement in 8 weeks
PQQ group
Placebo
0
7
Cognitive domains improved vs placebo
Cognitive improvement in 8 weeks
PQQ group
Placebo
0
7
More consistent energy from rebuilt NAD+
Sharper focus and faster mental speed
Better daily recovery and resilience
Healthier aging for skin and cells
Practitioner Recommended
Designed with experts. Engineered for outcomes.
Core100 is developed with functional health experts and PhD researchers.
It's based on cellular biology, nutritional biochemistry, and functional medicine literature.
Every batch is produced in a U.S. cGMP factility, and third-party lab tested for purity.
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Packages
Most popular
Quarterly Supply
$449
/quarter
$500
Why start with 90 days?
Core100 runs as a 90-day protocol because meaningful shifts in NAD+ metabolism, mitochondrial function, redox balance, and related systems show up over weeks to months, not days. The goal of the first three months is a higher, more reliable baseline you can feel in how your weeks run.
Bet value
Annual Supply
$1299
/year
Why upgrade to a full year?
Cellular energy and resilience respond to consistency. The first 90 days focus on building a stronger baseline; the following months are about maintaining and gradually strengthening it so you can keep handling a high-demand life without constantly feeling overdrawn.
One simple routine, sustained for long-term results.
The Facts About Core100
How do I take Core100?
Take three capsules once daily, ideally at the same time each day, and follow the directions on your label. You don’t need to split the dose.
Should I take Core100 with food, coffee, or other supplements?
Core100 can be taken with or without food. If you’re sensitive, start with a meal. Coffee is fine - Core100 contains no caffeine or classic stimulants.
Are there any side effects with Core100?
Core100 is stimulant-free and generally well tolerated. If anything feels unusual or concerning, stop and speak with your healthcare professional.
Is Core100 safe for long-term daily use?
Core100 is designed for daily use as part of an ongoing routine. If you have a medical condition, take prescription medication, or are pregnant/breastfeeding, review the label with your healthcare professional before starting or continuing long-term.
Where is Core100 made and how is it tested?
Core100 is produced in the USA at a cGMP-compliant facility, with third-party testing performed on each batch. Testing is used to confirm ingredient identity and verify purity and potency for consistent quality.
Get early access to Rerise
Beta Program
Be first to explore new therapies, product trials, and lab testing as we build what’s next.
The Facts About Core100
How do I take Core100?
Take three capsules once daily, ideally at the same time each day, and follow the directions on your label. You don’t need to split the dose.
Should I take Core100 with food, coffee, or other supplements?
Core100 can be taken with or without food. If you’re sensitive, start with a meal. Coffee is fine - Core100 contains no caffeine or classic stimulants.
Are there any side effects with Core100?
Core100 is stimulant-free and generally well tolerated. If anything feels unusual or concerning, stop and speak with your healthcare professional.
Is Core100 safe for long-term daily use?
Core100 is designed for daily use as part of an ongoing routine. If you have a medical condition, take prescription medication, or are pregnant/breastfeeding, review the label with your healthcare professional before starting or continuing long-term.
Where is Core100 made and how is it tested?
Core100 is produced in the USA at a cGMP-compliant facility, with third-party testing performed on each batch. Testing is used to confirm ingredient identity and verify purity and potency for consistent quality.
Get early access to Rerise
Beta Program
Be first to explore new therapies, product trials, and lab testing as we build what’s next.
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