The Mitochondrial Protocol
Core100 is a complete 13-active system for mitochondrial health and NAD+, built for cellular energy, metabolic function, redox balance, and healthy aging.
90-Day Subscription
$4.99/day
Save $51
$500
$449
Best value
One-Time Purchase
$5.54/day
Try the protocol for 90-days
$500
Shipped and billed once
Free U.S. shipping
Annual Subscription
$1,680
Third-Party Tested
Non-GMO
Additive-Free
Gluten-Free
U.S. GMP Certified
Made in USA
Five systems.
One protocol.
Increased NAD+
Randomized trials of NMN in adults 40–65 show meaningful rises in blood NAD+.
Stronger Defenses
Inflammatory markers across 20 RCTs
CRP
-0.69 mg/L
IL-6
-1.83 pg/mL
TNF-α
-0.45 pg/mL
Systematic review and meta-analysis of 20 RCTs; alpha-lipoic acid significantly lowered CRP, IL-6 and TNF-α versus placebo.
Cognitive Clarity
Randomized, double-blind trials of PQQ have found improvements in memory, attention, and processing speed versus placebo.
More consistent energy from supported NAD+
Support for focus and mental speed
Support for daily recovery and resilience
Support for healthy aging, skin, and cells
How Core100 works for you
Step 1 - Supports NAD+ recycling
Supports the NAD+ your cells use to convert calories into energy and maintain everyday cellular function.
Step 2 - Supports ATP production
Supports how your mitochondria process oxygen and nutrients into ATP, so cells have more fuel to draw on.
Step 3 - Enhances fuel delivery
Helps shuttle fuel into your mitochondria and keep their core enzymes performing well under everyday metabolic stress.
Step 4 - Strengthens oxidative defenses
Encourages renewal pathways and reinforces antioxidant defenses that support mitochondrial function over time.
Every ingredient has a functional role
Each active is mapped to a specific area of mitochondrial function — NAD+ metabolism, cellular energy production, redox balance, methylation, or metabolic flexibility — working as an integrated system.
Clinically studied ingredients. Clinically dosed. Third-party tested.
Core100 combines thirteen clinically-informed actives to support your body’s five core energy systems.
Compare approaches to mitochondrial health
Don't mistake add-ons for a complete mitochondrial protocol.
Real benefits you can feel
All reviews
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Sarah L., 41
Verified buyer
★★★★★
I've been taking Core100 for 3 months and just started my second order. The biggest change I've seen is not feeling as agitated before meals when I'm hungry - I'm able to just keep moving forward. I can't recommend this stuff enough, it works. Try it yourself and you'll see.
Mark T., 39
Verified buyer
★★★★★
I'm a founder who lifts weights 5x a week, my physician actually recommended I find a strong b-methylated vitamin and found th is is the best bang for my buck. My bench has gone up, I'm feeling really good in the mornings, and it's only been 5 weeks. I'm a fan.
David R., 48
Verified buyer
★★★★★
My afternoons are just lighter. I'm focusing better in meetings and feeling good. I just got my Mom taking Core100 too. Really happy with the results.
Lynne L., 52
Verified buyer
★★★★★
I can tell you this thing works - I feel younger than ever. Don't take it before bed though, it has some pretty powerful methylated B-Vitamins and can keep you up for a bit. Another reason how I know it's working!
Practitioner Recommended
Designed with experts. Built on evidence.
Core100 is developed with functional health experts and PhD researchers.
It's based on cellular biology, nutritional biochemistry, and functional medicine literature.
Every batch is produced in a U.S. cGMP facility, and third-party lab tested for purity.
