Additive-Free
U.S. GMP Certified
Additive-Free
U.S. GMP Certified
Additive-Free
U.S. GMP Certified
Additive-Free
U.S. GMP Certified
Additive-Free
U.S. GMP Certified
Additive-Free
U.S. GMP Certified
Additive-Free
U.S. GMP Certified
The Mitochondrial Protocol
Core100 is a 13-active mitochondrial protocol built across five cellular pathways to support energy, cognitive performance, and healthy aging.
More consistent energy
Improved focus and mental speed
Daily recovery and resilience
Support for healthy aging, skin, and cells
$99/mo
$149/mo
$149/mo
New -30% lower price
90-Day Subscription delivered and billed every 90 days. Pause or cancel anytime.
Two Rerise Biomarker Tests included.
Free U.S. shipping.
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Third-Party Tested
Non-GMO
Additive-Free
Gluten-Free
U.S. GMP Certified
Made in USA
How to use
90-Day Satisfaction Guarantee
The Mitochondrial Protocol
Core100 is a 13-active mitochondria and NAD+ protocol designed to support cellular energy, cognitive performance, and healthy aging.
More consistent energy
Improved focus and mental speed
Daily recovery and resilience
Support for healthy aging, skin, and cells
$99/mo
$149/mo
New -30% lower price
90-Day Subscription delivered and billed every 90 days. Pause or cancel anytime.
Two Rerise Biomarker Tests included.
Free U.S. shipping.
Third-Party Tested
Non-GMO
Additive-Free
Gluten-Free
U.S. GMP Certified
Made in USA
How to use
90-Day Satisfaction Guarantee
How to use
90-Day Satisfaction Guarantee
Five pathways.
One protocol.
1
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
2
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
3
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
4
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
5
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
1
Cellular energy metabolism
Supports NAD+ pathways and ATP production to support steady energy and clear thinking across long days.
2
Mitochondrial function
Promotes the generation and renewal of new mitochondria to support sustained demand.
3
Oxidative stress response
Strengthens mitochondrial antioxidants to help protect cells from everyday oxidative stress and damage.
4
Methylation
Supports methyl donors and B vitamins to keep methylation efficient for everyday cellular function.
5
Metabolic flexibility
Helps cells use both carbs and fats for fuel, supporting steadier energy and better adaptation.
Built for long-term health
Built for the long-term
Increased NAD+
Randomized trials of NMN in adults 40–65 show meaningful rises in blood NAD+.
Stronger Defenses
A meta-analysis found alpha-lipoic acid reduced key markers of inflammation and oxidative stress versus placebo.
A meta-analysis found alpha-lipoic acid reduced key markers of inflammation and oxidative stress versus placebo.
Inflammatory markers across 20 RCTs
CRP
-0.69 mg/L
IL-6
-1.83 pg/mL
TNF-α
-0.45 pg/mL
Systematic review and meta-analysis of 20 RCTs; alpha-lipoic acid significantly lowered CRP, IL-6 and TNF-α versus placebo.
Cognitive Clarity
Randomized, double-blind trials of PQQ have found improvements in memory, attention, and processing speed versus placebo.
Cognitive improvement in 8 weeks
PQQ group
Placebo
0
7
Cognitive domains improved vs placebo
Cognitive improvement in 8 weeks
PQQ group
Placebo
0
7
More consistent energy from supported NAD+
Support for focus and mental speed
Support for daily recovery and resilience
Support for healthy aging, skin, and cells
Benefits compounding over time
Core energy builds cell by cell, system by system, week by week.
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Hour
6
Early cell activation
Within the first few hours, mitochondrial nutrients are absorbed and begin feeding the machinery that turns food into usable energy.
Day
7
Smoother energy processing
B vitamins and methyl donors are building to steadier levels, supporting cleaner, more efficient daily energy metabolism.
Day
30
More efficient cellular recharge
Repeated dosing supports stronger NAD+ and mitochondrial enzyme activity, improving how cells recharge between everyday demands.
Day
60
Steadier everyday energy
Mitochondria-supporting nutrients work together so cellular energy output is more resilient and day-to-day stamina feels steadier.
Day
90
Built-up cellular resilience
Ongoing support for mitochondria, methylation, and antioxidant defenses reinforces the resilience of systems that drive energy and focus.
Day
180
A stronger baseline
Sustained nutrient levels support mitochondrial efficiency and healthy homocysteine metabolism over time.
Beyond
Ongoing cellular maintenance
Continued use maintains this mitochondrial and methylation support so cells keep pace with aging and modern stress.
Year
1
Encourages the growth of fresh, more resilient mitochondria
Year
2
Encourages the growth of fresh, more resilient mitochondria
Hour 6
Day 7
Day 30
Day 60
Day 90
Day 180
Beyond
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Day
1
Encourages the growth of fresh, more resilient mitochondria
Hour
6
Early cell activation
Within the first few hours, mitochondrial nutrients are absorbed and begin feeding the machinery that turns food into usable energy.
Day
7
Smoother energy processing
B vitamins and methyl donors are building to steadier levels, supporting cleaner, more efficient daily energy metabolism.
Day
30
More efficient cellular recharge
Repeated dosing supports stronger NAD+ and mitochondrial enzyme activity, improving how cells recharge between everyday demands.
Day
60
Steadier everyday energy
Mitochondria-supporting nutrients work together so cellular energy output is more resilient and day-to-day stamina feels steadier.
Day
90
Built-up cellular resilience
Ongoing support for mitochondria, methylation, and antioxidant defenses reinforces the resilience of systems that drive energy and focus.
Day
180
A stronger baseline
Sustained nutrient levels support mitochondrial efficiency and healthy homocysteine metabolism over time.
Beyond
Ongoing cellular maintenance
Continued use maintains this mitochondrial and methylation support so cells keep pace with aging and modern stress.
Year
1
Encourages the growth of fresh, more resilient mitochondria
Year
2
Encourages the growth of fresh, more resilient mitochondria
Hour 6
Day 7
Day 30
Day 60
Day 90
Day 180
Beyond
Hour
6
Early cell activation
Within the first few hours, mitochondrial nutrients are absorbed and begin feeding the machinery that turns food into usable energy.
Day
7
Smoother energy processing
B vitamins and methyl donors are building to steadier levels, supporting cleaner, more efficient daily energy metabolism.
Day
30
More efficient cellular recharge
Repeated dosing supports stronger NAD+ and mitochondrial enzyme activity, improving how cells recharge between everyday demands.
Day
60
Steadier everyday energy
Mitochondria-supporting nutrients work together so cellular energy output is more resilient and day-to-day stamina feels steadier.
Day
90
Built-up cellular resilience
Ongoing support for mitochondria, methylation, and antioxidant defenses reinforces the resilience of systems that drive energy and focus.
Day
180
A stronger baseline
Sustained nutrient levels support mitochondrial efficiency and healthy homocysteine metabolism over time.
Beyond
Ongoing cellular maintenance
Continued use maintains this mitochondrial and methylation support so cells keep pace with aging and modern stress.
Benefits compounding over time
Real energy doesn’t spike. It builds week by week, system by system
Hour 6
Day 7
Day 30
Day 60
Day 90
Day 180
Beyond
How Core100 works for you
Step 1 - Supports NAD+ recycling
Supports the NAD+ your cells use to convert calories into energy and maintain everyday cellular function.
Step 2 - Supports ATP production
Supports how your mitochondria process oxygen and nutrients into ATP, so cells have more fuel to draw on.
Step 3 - Enhances fuel delivery
Helps shuttle fuel into your mitochondria and keep their core enzymes performing well under everyday metabolic stress.
Step 4 - Strengthens oxidative defenses
Encourages renewal pathways and reinforces antioxidant defenses that support mitochondrial function over time.
Every ingredient has a functional role
Each active is mapped to a specific area of mitochondrial function — NAD+ metabolism, cellular energy production, redox balance, methylation, or metabolic flexibility — working as an integrated system.
NMN
Nicotinamide Mononucleotide
NMN
Nicotinamide Mononucleotide
Acetyl-L-Carnitine
ALCAR HCl
Acetyl-L-Carnitine
ALCAR HCl
Betaine
Trimethylglycine
Betaine
Trimethylglycine
Shilajit
PrimaVie®
Shilajit
PrimaVie®
CoQ10
UbiQsome® Phytosome™
CoQ10
UbiQsome® Phytosome™
R-Lipoic Acid
Bio-enhanced®
R-Lipoic Acid
Bio-enhanced®
Clinically studied ingredients. Clinically dosed. Third-party tested.
Core100 combines thirteen clinically-informed actives to support your body’s five core energy systems.
PQQ
PureQQ®
PQQ
PureQQ®
Niacin
Nicotinic Acid
Niacin
Nicotinic Acid
Vitamin B2
Riboflavin-5'-Phosphate
Vitamin B2
Riboflavin-5'-Phosphate
Vitamin B6
Pyridoxal-5'-Phosphate
Vitamin B6
Pyridoxal-5'-Phosphate
YuvaBio® Y100™
Terminalia Chebula
YuvaBio® Y100™
Terminalia Chebula
Folate
Quatrefolic
Folate
Quatrefolic
Vitamin B12
Methylcobalamin
Vitamin B12
Methylcobalamin
Compare approaches to mitochondrial health
Don't mistake add-ons for a complete mitochondrial protocol.
Compare
Foundation fit
Mito coverage
Pathways covered
Daily price
Third-party tested
Urolithin A
NAD+ Only
Multivitamin
DIY Stack
Foundational protocol
Add-On
Add-On
General
Custom
Broad
Narrow
Narrow
Untargeted
Broad
5
2
2
1
Varies
$3.30
$4.17
$3.87
$1.33
$10.36
COAs posted
Varies
Varies
Inconsistent
Inconsistent
Compare
Foundation fit
Mito coverage
Pathways covered
Daily price
Third-party tested
Urolithin A
NAD+ Only
Multivitamin
DIY Stack
Foundational protocol
Add-On
Add-On
General
Custom
Broad
Narrow
Narrow
Untargeted
Broad
5
2
2
1
Varies
$3.30
$4.17
$3.87
$1.33
$10.36
COAs posted
Varies
Varies
Inconsistent
Inconsistent
Real benefits you can feel
Carrie
Verified buyer
Respect the research
Dr. T
Verified buyer
Energy with Type I
Lillia M.
Verified buyer
Increased steady energy
Shannon M.
Verified buyer
Feeling stronger than ever
Jeff C.
Verified buyer
Supported my fertility journey
Doula S.
Verified buyer
Helped long work hours
Amelia D.
Verified buyer
No more burnout
Brianna M.
Verified buyer
Faster recovery in the gym
Sara C.
Verified buyer
Feeling less stressed
Dara R.
Verified buyer
Doctor recommended Core100
Nicole P.
Verified buyer
Carrie
Verified buyer
Respect the research
Dr. T
Verified buyer
Energy with Type I
Lillia M.
Verified buyer
Increased steady energy
Shannon M.
Verified buyer
Feeling stronger than ever
Jeff C.
Verified buyer
Supported my fertility journey
Doula S.
Verified buyer
Helped long work hours
Amelia D.
Verified buyer
No more burnout
Brianna M.
Verified buyer
Faster recovery in the gym
Sara C.
Verified buyer
Feeling less stressed
Dara R.
Verified buyer
Doctor recommended Core100
Nicole P.
Verified buyer
Carrie
Verified buyer
Respect the research
Dr. T
Verified buyer
Energy with Type I
Lillia M.
Verified buyer
Increased steady energy
Shannon M.
Verified buyer
Feeling stronger than ever
Jeff C.
Verified buyer
Supported my fertility journey
Doula S.
Verified buyer
Helped long work hours
Amelia D.
Verified buyer
No more burnout
Brianna M.
Verified buyer
Faster recovery in the gym
Sara C.
Verified buyer
Feeling less stressed
Dara R.
Verified buyer
Doctor recommended Core100
Nicole P.
Verified buyer
Carrie
Verified buyer
Respect the research
Dr. T
Verified buyer
Energy with Type I
Lillia M.
Verified buyer
Increased steady energy
Shannon M.
Verified buyer
Feeling stronger than ever
Jeff C.
Verified buyer
Supported my fertility journey
Doula S.
Verified buyer
Helped long work hours
Amelia D.
Verified buyer
No more burnout
Brianna M.
Verified buyer
Faster recovery in the gym
Sara C.
Verified buyer
Feeling less stressed
Dara R.
Verified buyer
Doctor recommended Core100
Nicole P.
Verified buyer
Carrie
Verified buyer
Respect the research
Dr. T
Verified buyer
Energy with Type I
Lillia M.
Verified buyer
Increased steady energy
Shannon M.
Verified buyer
Feeling stronger than ever
Jeff C.
Verified buyer
Supported my fertility journey
Doula S.
Verified buyer
Helped long work hours
Amelia D.
Verified buyer
No more burnout
Brianna M.
Verified buyer
Faster recovery in the gym
Sara C.
Verified buyer
Feeling less stressed
Dara R.
Verified buyer
Doctor recommended Core100
Nicole P.
Verified buyer
Carrie
Verified buyer
Respect the research
Dr. T
Verified buyer
Energy with Type I
Lillia M.
Verified buyer
Increased steady energy
Shannon M.
Verified buyer
Feeling stronger than ever
Jeff C.
Verified buyer
Supported my fertility journey
Doula S.
Verified buyer
Helped long work hours
Amelia D.
Verified buyer
No more burnout
Brianna M.
Verified buyer
Faster recovery in the gym
Sara C.
Verified buyer
Feeling less stressed
Dara R.
Verified buyer
Doctor recommended Core100
Nicole P.
Verified buyer
Carrie
Verified buyer
Respect the research
Dr. T
Verified buyer
Energy with Type I
Lillia M.
Verified buyer
Increased steady energy
Shannon M.
Verified buyer
Feeling stronger than ever
Jeff C.
Verified buyer
Supported my fertility journey
Doula S.
Verified buyer
Helped long work hours
Amelia D.
Verified buyer
No more burnout
Brianna M.
Verified buyer
Faster recovery in the gym
Sara C.
Verified buyer
Feeling less stressed
Dara R.
Verified buyer
Doctor recommended Core100
Nicole P.
Verified buyer
Carrie
Verified buyer
Respect the research
Dr. T
Verified buyer
Energy with Type I
Lillia M.
Verified buyer
Increased steady energy
Shannon M.
Verified buyer
Feeling stronger than ever
Jeff C.
Verified buyer
Supported my fertility journey
Doula S.
Verified buyer
Helped long work hours
Amelia D.
Verified buyer
No more burnout
Brianna M.
Verified buyer
Faster recovery in the gym
Sara C.
Verified buyer
Feeling less stressed
Dara R.
Verified buyer
Doctor recommended Core100
Nicole P.
Verified buyer
Carrie
Verified buyer
Respect the research
Dr. T
Verified buyer
Energy with Type I
Lillia M.
Verified buyer
Increased steady energy
Shannon M.
Verified buyer
Feeling stronger than ever
Jeff C.
Verified buyer
Supported my fertility journey
Doula S.
Verified buyer
Helped long work hours
Amelia D.
Verified buyer
No more burnout
Brianna M.
Verified buyer
Faster recovery in the gym
Sara C.
Verified buyer
Feeling less stressed
Dara R.
Verified buyer
Doctor recommended Core100
Nicole P.
Verified buyer
All reviews
5
5
5
5
5
5
4
5
5
5
5
5
5
5
5
5
4
5
5
5
5
Sarah L., 41
Verified buyer
★★★★★
I've been taking Core100 for 3 months and just started my second order. The biggest change I've seen is not feeling as agitated before meals when I'm hungry - I'm able to just keep moving forward. I can't recommend this stuff enough, it works. Try it yourself and you'll see.
Mark T., 39
Verified buyer
★★★★★
I'm a founder who lifts weights 5x a week, my physician actually recommended I find a strong b-methylated vitamin and found th is is the best bang for my buck. My bench has gone up, I'm feeling really good in the mornings, and it's only been 5 weeks. I'm a fan.
David R., 48
Verified buyer
★★★★★
My afternoons are just lighter. I'm focusing better in meetings and feeling good. I just got my Mom taking Core100 too. Really happy with the results.
Lynne L., 52
Verified buyer
★★★★★
I can tell you this thing works - I feel younger than ever. Don't take it before bed though, it has some pretty powerful methylated B-Vitamins and can keep you up for a bit. Another reason how I know it's working!
Practitioner Recommended
Designed with experts. Built on evidence.
Core100 is developed with functional health experts and PhD researchers.
It's based on cellular biology, nutritional biochemistry, and functional medicine literature.
Every batch is produced in a U.S. cGMP facility, and third-party lab tested for purity.
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Dr. Keshav Singh
Scientific Founder and Chief Scientific Officer, Yuva Biosciences, Inc.
Matt Carpenter
Expert Formulator
Jack Ukropina
Co-Founder
Conrad Ukropina
Co-Founder
Facts About Core100
How do I take Core100?
Take three capsules once daily, ideally at the same time each day, and follow the directions on your label. You don’t need to split the dose.
Should I take Core100 with food, coffee, or other supplements?
Core100 can be taken with or without food. If you’re sensitive, start with a meal. Coffee is fine - Core100 contains no caffeine or classic stimulants.
Are there any side effects with Core100?
Core100 is stimulant-free and generally well tolerated. If anything feels unusual or concerning, stop and speak with your healthcare professional.
Is Core100 safe for long-term daily use?
Core100 is designed for daily use as part of an ongoing routine. If you have a medical condition, take prescription medication, or are pregnant/breastfeeding, review the label with your healthcare professional before starting or continuing long-term.
Where is Core100 made and how is it tested?
Core100 is produced in the USA at a cGMP-compliant facility, with third-party testing performed on each batch. Testing is used to confirm ingredient identity and verify purity and potency for consistent quality.
Facts About Core100
How do I take Core100?
Take three capsules once daily, ideally at the same time each day, and follow the directions on your label. You don’t need to split the dose.
Should I take Core100 with food, coffee, or other supplements?
Core100 can be taken with or without food. If you’re sensitive, start with a meal. Coffee is fine - Core100 contains no caffeine or classic stimulants.
Are there any side effects with Core100?
Core100 is stimulant-free and generally well tolerated. If anything feels unusual or concerning, stop and speak with your healthcare professional.
Is Core100 safe for long-term daily use?
Core100 is designed for daily use as part of an ongoing routine. If you have a medical condition, take prescription medication, or are pregnant/breastfeeding, review the label with your healthcare professional before starting or continuing long-term.
Where is Core100 made and how is it tested?
Core100 is produced in the USA at a cGMP-compliant facility, with third-party testing performed on each batch. Testing is used to confirm ingredient identity and verify purity and potency for consistent quality.
Select a plan
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$449
Best value
Shipped and billed every 90 days
Subscribe and save $50 on every order
Free U.S. shipping; pause or cancel anytime
One-Time Purchase
$5.54/day
Try the protocol for 90-days
$500
Shipped and billed once
Free U.S. shipping; pause or cancel anytime
Select a plan
90-Day Subscription
$4.99/day
Save $51
$500
$449
Best value
Shipped and billed every 90 days
Subscribe and save $50 on every order
Free U.S. shipping; pause or cancel anytime
One-Time Purchase
$5.54/day
Try the protocol for 90-days
$500
Shipped and billed once
Free U.S. shipping; pause or cancel anytime
Free U.S. shipping; pause or cancel anytime
Select a plan
90-Day Subscription
$4.99/day
Save $51
$500
$449
Best value
Shipped and billed every 90 days
Subscribe and save $50 on every order
Free U.S. shipping; pause or cancel anytime
One-Time Purchase
$5.54/day
Try the protocol for 90-days
$500
Shipped and billed once
Free U.S. shipping; pause or cancel anytime
Free U.S. shipping; pause or cancel anytime