Improve your core mitochondrial health

Improve your core mitochondrial health

with

Core100 is the daily protocol for steady energy, sharper clarity and stronger resilience - built for people who expect proof over promises.

Featured in research and coverage

3079 reviews

★★★★★ 4.9/5

Core100 is the foundational 90-day protocol supporting mitochondrial function, NAD+ metabolism, and the cellular systems behind energy, cognition, and resilience.

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One-time purchase

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One-time purchase

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One time purchase

90 day supply $499

Best value

Third-Party Lab Tested for Purity

Made in a U.S. GMP-Certified Facility

Non-GMO, Additive-Free, Allergen-Free

Mitochondria-First, Clinically-Dosed Formula

How to use

Certificate of Analysis

How to use

Certificate of Analysis

Why You Need Core100

A protocol for your cellular energy systems.

Core100 supports the systems that set your capacity for energy, focus, and recovery through heavy weeks, so you’re less dependent on short-lived boosts.

What CORE100 strengthens

Your 90-day rebuild

Day

1

Encourages the growth of fresh, more resilient mitochondria

Day

1

Encourages the growth of fresh, more resilient mitochondria

Day

1

Encourages the growth of fresh, more resilient mitochondria

Day

1

Encourages the growth of fresh, more resilient mitochondria

Day

1

Encourages the growth of fresh, more resilient mitochondria

Day

1

Encourages the growth of fresh, more resilient mitochondria

Weeks

1-4

Foundation

You give your cells consistent support for NAD+, mitochondrial cofactors, and redox balance. Many people notice steadier mornings and fewer sharp afternoon crashes.

Day

30

More consistent output

As support accumulates, energy and focus can feel more even into the evening, with a bit more left in the tank after demanding days.

Day

60

Resilience building

Recovery from travel, training, and long work blocks can start to feel more predictable. Mood and mental stamina may feel more even across the week.

Day

90

A stronger baseline

Clearer focus, steadier energy, and better recovery begin to feel more like your default rather than the exception.

Beyond

Compounding resilience

Continued use is designed to help maintain and gradually strengthen that baseline as you move through heavy quarters and years.

Year

1

Encourages the growth of fresh, more resilient mitochondria

Year

2

Encourages the growth of fresh, more resilient mitochondria

Weeks 1-4

Day 30

Day 60

Day 90

Beyond

Weeks

1-4

Cellular ignition

Blow off the cobwebs, as mornings grow steady

Day

30

Mitochondrial boost

Noticeably more energy, where before there was fatigue

Day

60

Rejuvenation begins

Mood stabilizes, as body and mind strengthen as one

Day

90

Vitality restored

Thinking is now sharp and clear, focus high and sustained

Beyond

Ready for decades to come

Live on your own terms, slowing down your lifestyle only if you want to - not because your body can’t keep up with your plans and aspirations.

Year

1

Encourages the growth of fresh, more resilient mitochondria

Year

2

Encourages the growth of fresh, more resilient mitochondria

What benefits to expect?

Real energy doesn’t spike. It builds week by week, system by system.

Weeks 1-4

Day 30

Day 60

Day 90

Beyond

Built for long-term capacity.

Built for long-term capacity.

Core100 is a clinically informed protocol with 13 actives that support the cellular energy systems at the core of how your weeks feel.

Core100 is a clinically informed protocol with 13 actives that support the cellular energy systems at the core of how your weeks feel.

NAD+ Restored

NAD⁺ drivers cellular energy. CORE100’s ingredients have been shown to increase NAD⁺ by up to 38% in 8 weeks, supporting steady daily energy without stimulants.

Strengthened Defences

Clinical studies show reductions of 20-35% in inflammatory biomarkers such as CRP and MDA. This supports faster recovery and stronger defence against daily stress.

Cognition Improved

Within 12 weeks, clinical trials show improvements in memory, focus, and cognitive speed - evidence that clarity can be rebuilt at any age.

Baseline

After 12 weeks

Support mitochondrial function and efficiency

Help manage oxidative stress and support redox balance

Support cellular repair and renewal

Strengthen long-term resilience and recovery capacity

What Our Customers Are Saying

3079 reviews

★★★★★ 4.9/5

What Our Customers Are Saying

3079 reviews

★★★★★ 4.9/5

What Our Customers Are Saying

3079 reviews

★★★★★ 4.9/5

Ingredient Spotlight

Every ingredient has a role. Every dose has a reason.

Every ingredient has a role. Every dose has a reason.

Core100 combines clinically informed actives in transparent doses.

No fillers. No proprietary blends. 

Each ingredient is mapped to one or more key areas: NAD+ metabolism, mitochondrial function, cellular defense and redox balance, neuro-energetics, and cellular repair.

Core100 combines clinically informed actives in transparent doses.

No fillers. No proprietary blends. 

Each ingredient is mapped to one or more key areas: NAD+ metabolism, mitochondrial function, cellular defense and redox balance, neuro-energetics, and cellular repair.

R-Lipoic Acid

Bio-Enhanced® NaRLA

Vitamin B12

Methylcobalamin

Terminalia chebula

as YuvaBio® Y100™

Vitamin B6

Pyridoxal-5'-phosphate

Purified Shilajit Extract

PrimaVie®

NMN

(Nicotinamide mononucleotide)

No fillers.
No blends.
No additives. Ever.

Fourteen clinically-dosed actives, each selected to rebuild your body's five core energy systems. Every batch is third-party lab tested for purity.

Folate (5-methyltetrahydrofolate)

Quatrefolic®

PQQ

Pyrroloquinoline Quinone as PureQQ®

Acetyl-L-Carnitine

(ALCAR HCl)

Trimethylglycine

Betaine

Niacin

Nicotinic acid

CoQ10

UbiQsome® Phytosome™

Vitamin B2

(Riboflavin-5'-Phosphate)

How CORE100 Works

Step 1 - One daily routine

Three capsules daily, with or without food, at roughly the same time each day.

Step 2 - Supporting your core energy systems

Core100’s ingredients support NAD+ metabolism, mitochondrial function, redox balance, methylation, and metabolic flexibility - the systems that shape how your cells produce and repair energy under load.

Step 3 - Backing ATP Production

By supporting these pathways, Core100 helps the processes that generate ATP - the cellular energy currency behind how you feel - run more efficiently across the day.

Step 4 - A stronger baseline

Week by week, consistent use is designed to translate that cellular support into steadier energy, sharper clarity, and stronger resilience through heavy weeks.

Practitioner Endorsement

Developed with experts. Grounded in research-based evidence.

Core100 is developed alongside functional health experts and PhD-level researchers. 

The formulation is built from cellular biology, nutritional biochemistry, and functional medicine literature, mapped to the core systems of energy and resilience.

Every batch is produced in a US cGMP facility and third-party tested for purity and consistency, so what’s on the label is what’s in the capsules.

Packages

Most popular

Quarterly Supply

$4.99

/daily

Why 90 days

Core100 runs as a 90-day protocol because meaningful shifts in NAD+ metabolism, mitochondrial function, redox balance, and related systems show up over weeks to months, not days. The goal of the first three months is a higher, more reliable baseline you can feel in how your weeks run.

Bet value

Annual Supply

$3.60

/daily

Why a full year

Cellular energy and resilience respond to consistency. The first 90 days focus on building a stronger baseline; the following months are about maintaining and gradually strengthening it so you can keep handling a high-demand life without constantly feeling overdrawn.

One simple routine, sustained for long-term results.

The Facts About Core100

How do I take Core100 each day?

Take three capsules once per day, at roughly the same time each day. Core100 is designed as a simple, once-daily routine so you’re more likely to stay consistent over 90 days and beyond. You don’t need to split the dose. Most people choose morning use so they can track how energy and focus feel across the day. Always follow the label instructions on your bottle.

Should I take Core100 with food, coffee, or other supplements?

Core100 can be taken with or without food; many people prefer to take it with breakfast or their first meal so it becomes part of a predictable routine. It can sit alongside most common supplements, but if you’re already on a complex protocol, it helps to review your full stack with a practitioner to avoid unnecessary overlap. If you’re sensitive to supplements in general, start with food and see how you feel.

What happens if I miss a day of Core100?

Missing a single day isn’t a problem—just resume your normal three-capsule routine the next day. Core100 is built around cumulative, day-over-day support for your mitochondrial and NAD+ systems, so consistency over weeks and months matters more than perfection. There’s no need to “double up” the next day. If you miss several days, just restart your daily routine and treat your 90-day window as a practical guide rather than a rigid countdown.

Are there any side effects with Core100?

Most people are expected to tolerate Core100 well, given it’s stimulant-free and uses ingredients at doses similar to those studied in humans. As with any supplement, individuals can respond differently; very occasionally, people may notice digestive changes or mild adjustment effects when starting a new protocol. If you notice anything that feels unusual or concerning, stop taking the product and speak with your healthcare professional.

Do you ship Core100 to my country?

Shipping availability and delivery times depend on your location and the latest logistics setup. We maintain an up-to-date list of countries we ship to, estimated delivery windows, and shipping costs on our Shipping & Returns page at checkout. Before you order, check that page to confirm we can ship to your address and to see current timelines and fees.

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Be first to explore new therapies, product trials, and lab testing as we build what’s next.

The Facts About Core100

How do I take Core100 each day?

Take three capsules once per day, at roughly the same time each day. Core100 is designed as a simple, once-daily routine so you’re more likely to stay consistent over 90 days and beyond. You don’t need to split the dose. Most people choose morning use so they can track how energy and focus feel across the day. Always follow the label instructions on your bottle.

Should I take Core100 with food, coffee, or other supplements?

Core100 can be taken with or without food; many people prefer to take it with breakfast or their first meal so it becomes part of a predictable routine. It can sit alongside most common supplements, but if you’re already on a complex protocol, it helps to review your full stack with a practitioner to avoid unnecessary overlap. If you’re sensitive to supplements in general, start with food and see how you feel.

What happens if I miss a day of Core100?

Missing a single day isn’t a problem—just resume your normal three-capsule routine the next day. Core100 is built around cumulative, day-over-day support for your mitochondrial and NAD+ systems, so consistency over weeks and months matters more than perfection. There’s no need to “double up” the next day. If you miss several days, just restart your daily routine and treat your 90-day window as a practical guide rather than a rigid countdown.

Are there any side effects with Core100?

Most people are expected to tolerate Core100 well, given it’s stimulant-free and uses ingredients at doses similar to those studied in humans. As with any supplement, individuals can respond differently; very occasionally, people may notice digestive changes or mild adjustment effects when starting a new protocol. If you notice anything that feels unusual or concerning, stop taking the product and speak with your healthcare professional.

Do you ship Core100 to my country?

Shipping availability and delivery times depend on your location and the latest logistics setup. We maintain an up-to-date list of countries we ship to, estimated delivery windows, and shipping costs on our Shipping & Returns page at checkout. Before you order, check that page to confirm we can ship to your address and to see current timelines and fees.

Get early access to Rerise

Beta Program

Be first to explore new therapies, product trials, and lab testing as we build what’s next.

Money-Back Guarantee

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